Using the Goldilocks Principle to model coral ecosystem engineering

Oncogene-induced autophagy and the Goldilocks principle.

Although several oncogenes enhance autophagic flux, the molecular mechanism and consequences of oncogene-induced autophagy remain to be clarified. We have recently shown that expression of oncogenic H-Ras (V12) promotes autophagy through upregulation of Beclin 1 and the BH3-only protein Noxa. H-Ras-expressing cells undergo autophagic cell death as a result of Noxa-mediated displacement of Mcl-1...

The Goldilocks Principle: Reading Children's Books with Explicit Memory Representations

We introduce a new test of how well language models capture meaning in children’s books. Unlike standard language modelling benchmarks, it distinguishes the task of predicting syntactic function words from that of predicting lowerfrequency words, which carry greater semantic content. We compare a range of state-of-the-art models, each with a different way of encoding what has been previously re...

the use of appropriate madm model for ranking the vendors of mci equipments using fuzzy approach

abstract nowadays, the science of decision making has been paid to more attention due to the complexity of the problems of suppliers selection. as known, one of the efficient tools in economic and human resources development is the extension of communication networks in developing countries. so, the proper selection of suppliers of tc equipments is of concern very much. in this study, a ...

The Goldilocks principle and antibiotic resistance in bacteria.

We have designed and fabricated a microecology to mimic a naturally occurring bacterial culture, which includes the stress gradient, metapopulation, and cellular motility. In this microecology, we show that it is possible to fix the resistance to the mutagenic antibiotic Ciprofloxacin in wild-type Escherichia coli within 10 h. We found the evolution of resistance is further accelerated in micro...

Treatment of metastatic epidural spinal cord compression: the Goldilocks principle.